Which syndrome is associated with migratory thrombophlebitis and malignancy?

• A. Virchow’s syndrome
• B. Trousseau syndrome
• C. Hoffman syndrome
• D. Paget's disease

Answer: (B)

Trousseau syndrome is associated with migratory thrombophlebitis and is often linked to an underlying malignancy, particularly pancreatic or lung cancer. This syndrome manifests as spontaneous thrombosis and inflammation of veins, which can change locations over time—hence the term "migratory thrombophlebitis." This phenomenon is due to the procoagulant state induced by certain malignancies, which can release clotting factors and promote clot formation leading to vascular complications.

Understanding the connection between Trousseau syndrome and malignancy is crucial in clinical practice because recognizing this syndrome may prompt further investigation for an underlying cancer, potentially allowing for earlier diagnosis and treatment of malignancy, which can significantly affect patient outcomes.